The move follows the acquisition of the spirits brands by Sazerac from Brown-Forman announced in January.
Hi-Spirits already handles other Sazerac brands in the UK.
Managing director Dan Bolton said: “Southern Comfort and Tuaca are both iconic brands, and a great fit with our expanding portfolio.
“With strong consumer followings we are looking forward to building further distribution across the UK on-trade, off-trade and travel retail channels.”
The new additions joins a Hi-Spirits portfolio that includes Buffalo Trace bourbon, Fireball and Antica sambuca.