The 4.3% abv ale was launched seven months ago in a partnership between the Whatever You Want rockers and Wychwood brewery.
It picked up a listing at Morrisons, along with various off-licences across the UK and Europe, and sales are now soaring.
Guitarist and singer Francis Rossi said: “This is incredible news - we haven't seen sales figures like that since the 1970s. People seemed to love Piledriver from the moment we launched it, and that success just kept rolling.”
Chris Keating, marketing manager at Wychwood, added: "We're overwhelmed – the reception from the fans has been amazing. Word has spread about what a great beer Piledriver is, because it's not just Quo fans who are buying it - beer fans are too.”