Volunteers were sent into 151 businesses in Stratford, West Ham, Upton Park and Plaistow at least four times during the operation.
The council was cracking down on retailers selling alcohol to children, selling alcohol outside licensing hours and stocking cigarettes and alcohol without paying excise duty.
Six retailers have lost their licences, two more have seen their licences suspended and conditions attached, and 10 are under review.
Store owners and sales assistants have been interviewed under caution as the council teamed up with the police for the crackdown, named Operation Missouri.
Cllr Ian Corbett, mayoral advisor for environment and leisure at Newham council, said: “This intense operation shows how Newham Council is working hard to protect residents from unscrupulous businesses who break the law for a quick buck. Our enforcement teams have carried out a thorough and fair investigation of these off licences.
“Six irresponsible licensees have already had their licences revoked and several more are currently under review. We will be looking to hear how they intend to mend their ways at the upcoming hearings or we will take stringent action.”