The winning beer will be chosen by an expert panel and will be available in 60 Waitrose shops from October 2014.
Thornbridge will use the entrant’s recipe and transform it into a commercial craft beer.
Waitrose beer buyer Kate Prall said: “This is a hugely exciting project for us, and it comes at a very important time in the history of craft breweries.
“The resurgence in popularity of both craft breweries and people trying out their own homemade beers means that we’re bound to get some amazing entries to our competition, which we’re looking forward to tasting.”
Rob Lovatt, head brewer at Thornbridge, added: “A considerable number of home brewers develop great quality beers that can never be appreciated by a larger drinking public. The Home Brew Challenge 2014 will provide home brewers with an opportunity to match their beers against those of other enthusiasts, and have them tasted by a panel of expert beer judges.
“The Home Brew Challenge 2014 will be a celebration of the British tradition of brewing with the aim of creating a great new beer and for people to try and embrace many of the new flavours in beers from across the world.”