The new store, on Abbeville Road, will offer more than 450 wines, with a particular emphasis on Portugal and Italy.
It will be equipped with Enomatic machines to offer shoppers the chance to try up to 16 wines.
All wines are colour-coded and come with food matching suggestions, while in-store tutored tastings will provide further education to shoppers.
Owner Andrew Eakin said: “Abbeville Road is a community within Clapham that we knew Bottle Apostle would feel at home in. The focus on supporting independents is clearly important to residents and is a large reason for our previous success in both Hackney and Crouch End.
“This is such an exciting time for independent merchants to thrive in London. The growing demand for unique wines, spirits and craft beers is a driving force behind our expansion to athird shop. Customers are demanding informative service offered in an approachable, friendly environment.”
Clapham will also be home a craft beer and cider section called The Brew Testament, which offers shoppers the chance to try local brews and drinks from further afield, along with a dedicated spirits selection.