The distillery will be developed on a 69-acre site at Ballard and Clonminch on the outskirts of Tullamore, bringing whiskey production back to the town for the first time since the original distillery closed in 1954.
The development will be part of a long term plan which will include a pot and malt distillery building, warehousing, offices, an employee car park and visitor facilities.
Work on the Tullamore Dew distillery will begin in April and should be finished by the summer of 2014, creating 100 construction jobs in the area.
The project follows the redevelopment of the Tullamore Dew Visitor Centre which opened in September 2012.
The new distillery will utilise the latest green technology and will meet the long-term production demands for Tullamore Dew, which is currently growing by more than 15% annually.
Global brand director Shane Hoyne said: “We are pleased that planning permission for the distillery has been granted and the construction phase can now commence. This new distillery is a significant step in the journey of Tullamore Dew, which is now the second largest selling Irish whiskey worldwide.
“It is also an important development for the town of Tullamore and part of our continuing investment in the region following the redevelopment of our Visitor Centre in 2012. We look forward to building a state-of-the-art distillery, and we are very proud to be bringing whiskey distilling back to Tullamore D.E.W.’s roots for the first time in almost 60 years.”