The new-build site will be the core part of its £1 billion invetment in malt whisky production capacity outlined by the Johnnie Walker producer earlier this year.
Diageo has submitted applications to Highland Council for a possible devel- opment at Teaninich, Rossshire, and to Moray Council for developments at Glendullan and Inchgower on Speyside.
All three sites are adjacent to existing Diageo distilleries.
The proposals also include expansion plans for the distilleries at Teaninich and Glendullan.
Malt distilling director Brian Higgs said: “We are still working to finalise the location of the new distillery, but it will be one of the three sites where we have submitted pre-planning applications.
“It’s necessary for us to begin the planning application at all three potential locations, so we will be able to move forward as quickly as possible with construction once our final location decision has been made.”
Rival Pernod Ricard has also revealed tentative plans to build a new distillery in Scotland.
Christian Porta, managing director of its Chivas Brothers division, told analysts in London that a new-build plant was likely “at some stage”.
Pernod Ricard will reopen the Glen Keith distillery next year to increase its production capacity.
Major producers are seeking to increase production capability in response to high global demand for Scotch whisky.