Ads will appear in Metro, The Sun and The Independent, as well as male-oriented magazines such as Stuff, Four Four Two and Empire.
There will be a regional bias towards Newcastle, Birmingham and Manchester with local press and outdoor advertising.
The campaign is aimed at 30-plus “urban-dwelling” men and will position the brand as a beer than can deliver the refreshment of a lager and the flavour of an ale.
Marketing director Jon Edwards said: “The campaign plays respect to the brand’s Geordie heritage while highlighting its benefit of delivering both flavour and refreshment.
“Newcastle Brown is an iconic brand, loved by millions, and the tone of the campaign aims to encourage more young, urban males to identify with the brand.”