The ad carries on the brand’s Good Things Come To Those Who Wait campaign and shows an Argentinian village transfixed by an epic domino-toppling event which ends in a giant pint of Guinness made up of toppling books.
Sixty, 90 and 30-second versions of the ad will run on TV, in cinemas and online. It is also being backed by online competitions - a first for Guinness - and print ads.
Overall Diageo is spending £10 million on the campaign, which runs until April, including POS materials for supermarkets, convenience stores and cash and carries.
Marketing manager Paul Cornell said: “It is the most expensive ad we’ve made and the most complex. The overall idea is that it is the most awe-inspiring celebration of Guinness ever - a community coming together to celebrate Guinness.”