The decision to change leaders has been described as amicable and comes at a time when Carlsberg is achieving the fastest growth of any top 10 lager.
Clydesdale will be succeeded by Isaac Sheps, 59, who will take on the role in addition to his current position as chief executive of Carlsberg South East Europe.
Carlsberg Group president and chief executive officer Jørgen Buhl Rasmussen said: "We are now entering a new phase of development and the ambition is to bring the UK's earnings closer in line with Carlsberg's targets for
"Given his track record at Carlsberg South East Europe , his readiness to challenge status quo and his ability to lead from the front, we are convinced
Isaac Sheps is the right man to take Carlsberg UK to the next level."
Clydesdale, who spent 11 years with Carlsberg, is now "looking for fresh challenges".
praised Clydesdale for his contribution and said Carlsberg UK had "clearly demonstrated good improvements" under his leadership.