A £6 million package was announced by public health minister Dawn Primarolo, at the National Alcohol Conference in Nottingham.
It will include the appointment of regional alcohol managers to push forward alcohol treatment and advice at a local level.
There will also be improved statistics gathering to monitor problems, increased access to specialist treatment, and advice aimed at getting 250,0000 men and 70,000 women to bring their drinking down to lower risk levels.
A further £1 million will be spent on an Alcohol Learning Centre that will provide support based on best practice from the 20 areas.
Primarolo said: “We clearly have a serious problem that needs urgent attention.
“Starting with the most deprived areas in inequality hotspots, we are going to roll out a new programme which will identify and help drinkers who are at risk.
“For every £1 spent on intervention, £5 is saved by the public purse, so this is money well spent.”