The ad is part of the first ever global advertising for the Diageo-owned brand.
The edit shown in the UK will see a toast to “Arthur” [Guinness, the brewery’s founder] mutate to “farmers”, “llamas” and “parsnips” as it travels from person to person around the globe.
There will also be a worldwide promotion with a top prize of a trip into space courtesy of Guinness and Virgin Galactic.
The celebrations peak on Sept 24 with a series of Arthur’s Day events in major cities including Dublin and New York.
Global marketing manager Ronan Beirne said: “Guinness is one of the world’s most iconic brands and we feel it is a fitting tribute to use this milestone to launch our first ever global ad campaign.”