It’s the second time the Stoke-based brewer’s beer has won the accolade in five years and it has been in the top three for five out of the last six years.
The silver award went to Yewbarrow from the Cumbrian micro Great Gable, with Coors-owned Worthington White Shield picking up the bronze prize.
Titanic managing director Keith Bott said he was “over the moon to be recognised as the best real ale in Britain”.
Camra has used the GBBF to launch a campaign to remove duty from all beers under 2.8% abv.
The organisation says the move would save consumers money and promote responsible drinking.
Chief executive Mike Benner said: “Zero duty on lower-strength beers is a win-win scenario for brewers, pubs, consumers and the government.
“Quality lower-strength beers can be backed with flavour – a lower-alcohol content does not need to translate into a reduction in flavour.”
The call was backed by Alcohol Concern, whose chief executive Don Shenker said: “People are entitled to have more choice and greater control over their own drinking.”