The retailers each picked up 62 awards for their own-label wines, with M&S bagging five golds.
Sainsbury’s received 59 awards, Asda 56 and Waitrose 18.
Gold medals wines included Asda’s Extra Special Riesling, the Co-op's Leyda Valley Sauvignon, M&S Moscatel Rosado, Sainsbury’s Taste the Difference Gavi and Waitrose Reserve Shiraz.
The IWC received a 15% increase in entries over 2009, with a record 46 countries supplying wine for judging.
Of the 7,726 medals awarded in all, 326 were gold and 1,445 silver, both 14% ahead of last year.
France remained at the top of the international league table with 947 medals and 75 golds.
Austrlaia was next with 602 medals and 65 gold.
Italy was third for total medals with 394, but Portugal outscored it on golds with 35.
Gold medals also went to two English wines: Camel Valley Pinot Noir Rosé Brut and Nyetimber Blanc de Blancs.
IWC event director Chris Ashton said: “Wines carrying the IWC logo and medal recognition enjoy significant commercial advantages.
“IWC award winners feature in the global media coverage generated by the competition, which enhances the wine’s credibility among consumers internationally and drives up sales.”